Evonik’s EUDRAGIT® polymers enable gastrointestinal tract targeting, along with improved protective, sustained-release and solubility performance. Copolymer, EUDRAGIT L 30 D is the aqueous dispersion of anionic polymers with methacrylic acid as a functional group. Physical properties: It is a. Pellets were coated with Eudragit L 30 D using fluidized bed processor. Different weight gains of acrylic polymer were applied onto the pellets and evaluated.

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All the reagents and solvents used were of analytical grades.

EUDRAGIT® L 30 D-55 Spray Suspension Formulation

The percentage friability was calculated from the pellet weight before and after fluidization [ 8 ]. Shaker was shaken for 20 min, particles retained on different sieves were collected and average pellets size was determined. Developed system was found to be suitable for the delivery of Sod PAS in to intestinal region.

Login to see your most recently eueragit materials here. The multiparticulate formulation of sodium para aminosalicylate for oral administration was developed by extrusion spheronization technique. Drug turns brown when comes in contact with air due to oxidation of phenolic group in benzene moiety, therefore 0. The carboxylic groups ionize in aqueous media at pH 5. Highly water-soluble drugs require higher polymer coating levels than poorly soluble compounds for sustained or delayed drug release.

Subcoating has been proposed by many scientists [ 4 – 6 ] as a method to improve the acid resistance for enteric coated dosage forms. The enteric polymer, Eudragit Eudragi D 55 is anionic copolymer contained free carboxylic groups in ratio of 1: Questions or comments about MatWeb?

An over coat was added to Sod PAS pellets that were coated with Eudragit L330 30 D to prevent the sticking of the pellets during dissolution studies and storage.

Pellets | Extrusion/spheronization | Eudragit L 30 D55 | Fluidized Bed Coater | Enteric-coated

A magnetic stirrer was used to continually mix the coating dispersion during the coating process to prevent wudragit. Ten percent aqueous solution of PEG 8. To see MatWeb’s complete data sheet for this material including material property data, metal compositions, material suppliers, etcplease click the button below. Sod PAS containing pellets mesh were coated with the aqueous coating dispersion in a fluid-bed coater.


The particles were vacuumed, dried and coated with gold palladium and observed microscopically. Users requiring more precise data for scientific or engineering calculations can click d555 the property value to see the eudrsgit value as well as raw conversions to equivalent units. A g of batch of pellets was placed in the fluid bed coater and pre warmed for 10 min prior to the spraying.

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Pellet size and size distribution was determined for coated pellets with different weight gain and it was found to be narrow in distribution fig. The focus of the present study was to produce pellets as multi-particulate delivery system, because of its advantages over monolithic dosage forms.

Coating was performed in fluidized bed coater under conditions as listed in Table 2. Please read our License Agreement regarding materials data and our Privacy Policy. Eudragit has a tendency to swell and form a lump in the basket due to which pellets were not properly exposed to the dissolution media.

Hence it was decided to give a seal coat to protect the drug. Or if you don’t have an account with us yet, then click here to register. The effect of the polymethacrylate copolymer coating system and weight gain applied were evaluated for in vitro release in order to obtain delayed release.

We appreciate your input. Processing parameters are given in Table 1.

Please contact us at webmaster matweb. It is a milky-white liquid of low viscosity with a faint characteristic odor. The acrylic polymer coating suspensions were prepared by adding water to the commercially available Eudragit L30 D Process conditions and parameters used for preparation p30 g batch of optimized pellets.

It was seen that the drug release from the coated pellets depended on the pH of the dissolution medium as well as weights applied. Following materials were used for the development of multiparticulate system: Parameters Value Spheronization speed rpm Eydragit load g Spheronization time 2 minute Amount of granulation liquid 65 ml Screen used 1.


Acrylates Copolymer Information provided by Evonik. Average pellet size was determined by sieve analysis and found to be The total out put of extrudate is mainly governed by the extrusion speed.

Click here to view all the property values for this datasheet as they were originally entered into MatWeb. On the basis of physical properties and dissolution behavior formulation F4 was taken as optimized formulation. Optimized process conditions and parameters are listed in Table 1. Acrylates Copolymer Information provided by Evonik Vendors: Dissolution studies were carried out in USP apparatus I basket using ml of 0.

The results indicated that it is possible to prevent the acidic degradation of sod PAS in upper GI tract which ultimately affect the bioavailability of drug and will help to reduce the dose, by development of multiparticulate system eudrxgit with pH dependent polymers using extrusion spheronization technique and fluidized bed processor. Shape and surface characteristics were determined by scanning electron microscope using gold sputter technique.

Bulk density was calculated as the quotient of the weight and volume of pellets. Size of the pellets was determined by sieve shaker analysis.

At lower speed rpm dumbbell shaped and irregular pellets were observed. Coating was applied by fluidized bed eusragit under parameters listed in Table 2.

Media were agitated at rpm and samples were taken at regular intervals, filtered through 0. The dispersion was stirred slowly to avoid the production of air bubbles. Surface morphology of developed pellets were investigated under scanning electron microscope which revealed a smooth and spherical surface fig.

MatWeb is intended for personal, non-commercial use. Subcoating of pellets is done to improve acid resistance of entericcoated dosage forms.

Poly methacrylic acid-co-ethyl acrylate 1: