Colistimethate sodium or pentasodium colistinmethanesulfonate ( mg Please see product packaging and package insert for complete expiration date and. PACKAGE INSERT. Colistimethate for Injection- resistant chronic infections due to colistin sensitive strains of gram-negative pathogenic bacilli. It is particularly. Colistin Package Insert PDF – Free download as PDF File .pdf), Text File .txt) or read online for free. Colistin-package-insert-pdf.
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Concomitant use of intravenous colistimethate sodium with other medications that are potentially nephrotoxic or neurotoxic should be undertaken with great caution.
Further, the effect of cplistin renal and metabolic function on the conversion of colistimethate sodium to colistin is not known. The use of intrathecal or intraventricular colistin package insert of colistimethate sodium in the treatment of meningitis was not systematically investigated in clinical trials and is supported by case coliwtin only.
As necessary, expert advice should be sought when the local prevalence of colistin package insert is such that the utility of the agent, in at least some types coljstin infections, is questionable. Name of the medicinal product 2.
In the absence of compatibility studies, reconstituted Colistimethate sodium must not be mixed with other medicinal products. Resistance Resistant bacteria are characterised by modification of the phosphate groups of lipopolysaccharide, which become substituted with ethanolamine or aminoarabinose.
In case colistin package insert an allergic reaction, treatment with colistimethate sodium must be discontinued and appropriate measures implemented. The most appropriate time interval to the first maintenance dose has not been established.
High serum concentrations of colistimethate sodium, which may be associated with overdosage or failure to reduce the dosage in patients with renal impairment, have been reported to lead to neurotoxic effects such as facial paraesthesia, muscle weakness, vertigo, slurred speech, colistln instability, visual disturbances, colostin, psychosis and apnoea.
Hydrolysis of colistimethate is significantly increased when reconstituted and diluted below its critical micelle concentration of about 80, IU per ml. Colistimethate should be used in pregnancy only if the benefit to the mother outweighs the potential risk to the foetus. During reconstitution swirl gently to avoid frothing. Renal function monitoring should be performed at the start of colistin package insert and regularly during treatment in all patients. A loading dose 9 MIU may be needed.
Enter medicine name or company Start typing to retrieve search suggestions. The data supporting the dose regimen in colistin package insert patients are very limited. The information on the pharmacokinetics of colistimethate sodium Colistin package insert and colistin is limited.
The loading dose applies to patients with normal and impaired renal functions including those on renal replacement therapy. Company contact details Beacon Pharmaceuticals. For single use only.
Reducing the dose colistin package insert alleviate symptoms. Colistimethate Sodium 1 Million I. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme. Intravenous colistimethate sodium does not cross the blood brain barrier to a clinically relevant extent. Effects may include apnoea, transient sensory disturbances such as facial paraesthesia and vertigo and, rarely, vasomotor instability, slurred speech, visual disturbances, confusion jnsert psychosis.
Posology The following dose recommendations colistin package insert made based on limited population-pharmacokinetic data in colistn ill patients see section 4.
The following conversion oackage is prepared for information and the values must be considered nominal and approximate only.
Due to the effects of colistin on the release of acetylcholine, non-depolarising muscle relaxants should colistin package insert used with caution in patients receiving colistimethate sodium as their effects could be prolonged see section 4. Patients should be warned not to drive or operate machinery colistin package insert these effects occur.
The volume of distribution is relevantly enlarged in critically ill subjects. Colistin clearance is colistin package insert in renal impairment, possibly due to increased conversion of CMS.
Confusion and medication errors have occurred because of the different expressions of dose in terms of potency.
Colistimethate Sodium 1 Million I.U. Powder for Solution for Injection
Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. Co-treatment with colistimethate sodium and macrolides such as azithromycin and clarithromycin, or fluoroquinolones such colistin package insert norfloxacin and ciprofloxacin should be undertaken with caution colidtin patients with myasthenia gravis see section 4. Last updated on eMC: Caution is advised when administering colistimethate sodium in these patients.