Carcinomas of the Ampulla of Vater are rare tumors, accounting for % of gastrointestinal cancers. Compared with other biliary tract. Metastasis of breast cancer to major duodenal papilla Palabras clave: Ampolla de Vater; Neoplasias de la mama; Ictericia (fuente: DeCS BIREME). Ampulla of Vater – TNM staging. T2: tumor invades into the muscularis propria of the duodenum; T3: tumor directly invades into the pancreas.

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The area within 2 cm of the ampulla is called periampullary region. Int J Surg Case Rep.

Narang et al[ 45 ] In another randomized study, patients with pancreatic or periampullary cancer received either adjuvant intra-arterial chemotherapy mitoxantrone, 5-FU, leucovorin, and cisplatinum combined with radiotherapy or no adjuvant treatment[ 41 ]. Please review our privacy policy. Combining gemcitabine and capecitabine in patients with advanced biliary cancer: Medical records of patients diagnosed with ampullary and other biliary tract tumors, observed at our Institution from to were reviewed.

This page was last edited on 26 Novemberat Combination therapy of resection and intraoperative radiation for patients with carcinomas of extrahepatic bile duct and ampulla of Vater: The cystic duct leaves the gallbladder and joins with the common hepatic duct to form the common bile duct.

Demographics, histological features, stage, treatment received and outcome of 20 cases of ampullary carcinoma. World J Gastrointest Oncol.

Ampulla of Vater

Median survival was Is postoperative adjuvant chemotherapy useful for gallbladder carcinoma? Krishnan et al[ 40 ] One phase III multicenter randomized trial tested the role of adjuvant chemotherapy in pancreatico-biliary carcinoma[ 46 ].

Associated with such findings, a 15 mm dilatation of the intra and extrahepatic biliary tree was observed by abdominal ultrasound. There is no conclusive data that confirm the usefulness of adjuvant radiotherapy or CCRT in biliary tract cancer whereas favorable results support the use of adjuvant chemotherapy. Author information Article notes Copyright and License information Disclaimer.

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An endoscopic ultrasound EUS was recommended, and it demonstrated infiltration of the injury until the muscular layer of the duodenal wall, without suspicious regional lymph nodes.

Ampulla of Vater – Wikipedia

The assessment and staging of ampullary neoplasms is based on several diagnostic modalities, including extracorporeal ultrasonography UScomputed tomography CTmagnetic resonance cholangiopancreatoscopy, fancer, endoscopic US EUSendoscopic-retrograde cholangiopancreatography, intraductal US IDUS and biopsy. Disappointingly, no significant survival advantage was vaater in cancer de ampolla de vater treatment group although CCRT produced a significant reduction in the appearance of liver metastases in periampullary tumors.

Predictors for patterns of failure after pancreaticoduodenectomy in ampullary cancer. Board review question 1. In this report we present a case of biliary obstruction due to metastatic breast cancer to the major duodenal papilla. Articles containing Latin-language text All articles with unsourced statements Articles with unsourced statements from June Wikipedia articles with TA98 identifiers.

Randomized controlled trial; CCRT: Thomas’ sign is the production of silver stools and can be indicative of cancer of the Ampulla of Vater. Malignant neoplasms affecting the major duodenal papilla are rare, and the adenocarcinoma is the histological type in almost all cases, but occasionally other histological types such as carcinoid tumors, squamous cell and mucinous carcinomas can be found 4.

Prophylactic gastrojejunostomy for unresectable periampullary carcinoma.

Although metastases of breast carcinomas are infrequent to the gastrointestinal tract, neoplasms of the juxtapapillary region should be suspected, especially at an early stage, since curative resection can be offered. Klinkenbijl et al[ 36 ] Duodenoscopic placement of biliary protheses to relieve malignant obstructive jaundice. A multicenter, international, open-label, randomized controlled phase III trial of adjuvant chemotherapy versus observation in patients with adenocarcinoma of the ampolls of vater.

Surgery represents the main therapeutic approach for ampullary cancer, whilst unresectable tumors can be treated with either radiotherapy or chemotherapy. In accordance with the literature, a longer median survival was observed in the group of ampullary cacner.


A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. By using this site, you agree to the Terms of Use and Privacy Policy. Regional lymph nodes pN.

Another phase II study evaluated outcomes in 29 patients with advanced ampullary adenocarcinoma using 3 different schedules with cisplatin and 5-FU or capecitabine or gemcitabine[ 65 ]. Registry data collection variables. Long-term survival and metastatic pattern of pancreatic and periampullary cancer after adjuvant chemoradiation or observation: A papillotomy was performed and a 10 French x 9 cm plastic stent was placed in the common bile duct.

Polypoid tumors of the major duodenal papilla: Histopathology, molecular features and clinical outcome clearly identify two distinct types of ampullary cancer, and their differences should be taken into account both in selecting medical treatments and in planning clinical trials. Patients with ampullary cancer underwent surgery more frequently than other biliary cancers while chemotherapy and radiotherapy were used equally.

Tumors of ampulla of Vater: A case series and review of chemotherapy options

In particular, we analyzed demographic characteristics, tumor histology, UICC stage, treatments employed and survival time for consecutive ampullary and biliary tract carcinoma patients. Pott G, Scharameyer B. Adjuvant chemoradiation versus surgery alone for adenocarcinoma of the ampulla of Vater. Metastasis of breast cancer to major duodenal papilla.

This duct subsequently joins with the pancreatic duct; this junction is known as the ampulla of Vater. Tis N0 M0 Stage I: Am J Surg Pathol.

The efficacy of a gemcitabine-based as compared to a 5FU-based adjuvant treatment was also emphasized by another trial, in which chemotherapy for 3 caner prior and for 12 wk after CCRT was administered[ 50 ]. Overall patients were divided in two treatment groups: Prognostic factors for ampullary adenocarcinomas: